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This book presents a new research agenda for improvements in Quality of Life research. It includes topics such as: -Studying QoL in particular subpopulations and selected subgroups -Disentangling the difficult task of identifying determinants of QoL -Perfectionating the measurement of conceptual dimensions -Defining new indicators able to measure and monitor particular social conditions and shows that these are not separated fields of studies but intersect each other and produce different outcomes which can be with difficulty classifiable, consistent with the idea of the complexity of our reality. The volume presents micro perspectives by taking into account the macro situation through both qualitative and quantitative approaches.