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This book provides a scientific framework for integrated solutions to complex energy problems. It adopts a holistic, systems-based approach to demonstrate the potential of an energy systems engineering approach to systematically quantify different options at various levels of complexity (technology, plant, energy supply chain, mega-system). Utilizing modeling, simulation and optimization-based frameworks, along with a number of real-life applications, it focuses on advanced energy systems including energy supply chains, integrated biorefineries, energy planning and scheduling approaches and urban energy systems. Featuring contributions from leading researchers in the field, this work is useful for academics, researchers, industry practitioners in energy systems engineering, and all those who are involved in model-based energy systems.