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This volume contains the proceedings of the AMS Special Session on Harmonic Analysis and Partial Differential Equations, held from April 21-22, 2018, at Northeastern University, Boston, Massachusetts. The book features a series of recent developments at the interface between harmonic analysis and partial differential equations and is aimed toward the theoretical and applied communities of researchers working in real, complex, and harmonic analysis, partial differential equations, and their applications. The topics covered belong to the general areas of the theory of function spaces, partial differential equations of elliptic, parabolic, and dissipative types, geometric optics, free boundary problems, and ergodic theory, and the emphasis is on a host of new concepts, methods, and results.