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This book constitutes the thoroughly refereed post-conference proceedings of the Second International Conference on Advances in New Technologies, Interactive Interfaces, and Communicability, held in Huerta Grande, Argentina, in December 2011. The 24 papers presented were carefully reviewed and selected from numerous submissions. The topics addressed span the entire spectrum of interactive design, e-commerce, e-learning, e-health, e-tourism, Web 2.0 and Web 3.0.