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This book discusses physical and mathematical models, numerical methods, computational algorithms and software complexes, which allow high-precision mathematical modeling in fluid, gas, and plasma mechanics; general mechanics; deformable solid mechanics; and strength, destruction and safety of structures. These proceedings focus on smart technologies and software systems that provide effective solutions to real-world problems in applied mechanics at various multi-scale levels. Highlighting the training of specialists for the aviation and space industry, it is a valuable resource for experts in the field of applied mathematics and mechanics, mathematical modeling and information technologies, as well as developers of smart applied software systems.