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An Introduction to Petroleum Reservoir Simulation is aimed toward graduate students and professionals in the oil and gas industry working in reservoir simulation. It begins with a review of fluid and rock properties and derivation of basic reservoir engineering mass balance equations. Then equations and approaches for numerical reservoir simulation are introduced. The text starts with simple problems (1D, single phase flow in homogeneous reservoirs with constant rate wells) and subsequent chapters slowly add complexities (heterogeneities, nonlinearities, multi-dimensions, multiphase flow, and multicomponent flow). Partial differential equations and finite differences are then introduced but it will be shown that algebraic mass balances can also be written directly on discrete grid blocks that result in the same equations. Many completed examples and figures will be included to improve understanding. An Introduction to Petroleum Reservoir Simulation is designed for those with their first exposure to reservoir simulation, including graduate students in their first simulation course and working professionals who are using reservoir simulators and want to learn more about the basics.