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Antony and Cleopatra is a well-known tragedy by William Shakespeare. Its first known appearance in print came in the First Folio of 1623. The plot is based on Thomas North’s translation of Plutarch’s Lives, and follows the relationship between Cleopatra and Mark Antony—from the time of the Sicilian revolt—to Cleopatra’s suicide during the Final War of the Roman Republic. Octavius Caesar is the major antagonist. He was Antony’s fellow triumviri of the Second Triumvirate and the first emperor of the Roman Empire, Augustus Caesar. The play is set in Rome and Egypt, and is marked by swift, panoramic shifts in geographical locations.