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This book is the result of 20 years of investigations carried out by the author and his colleagues in order to bring closer and, to a certain extent, synthesize a number of well-known results, ideas and methods from the theory of function approximation, theory of differential and integral equations and numerical analysis. The book opens with an introduction on the theory of function approximation and is followed by a new approach to the Fredholm integral equations to the second kind. Several chapters are devoted to the construction of new methods for the effective approximation of solutions of several important integral, and ordinary and partial differential equations. In addition, new general results on the theory of linear differential equations with one regular singular point, as well as applications of the various new methods are discussed.