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Beatriz Caiuby Labate and Clancy Cavnar offer an in-depth exploration of how Amerindian epistemology and ontology concerning indigenous shamanic rituals of the Amazon have spread to Western societies, and of how indigenous, mestizo, and cosmopolitan cultures have engaged with and transformed these forest traditions. The volume focuses on the use of ayahuasca, a psychoactive drink essential in many indigenous shamanic rituals of the Amazon. Ayahuasca use has spread far beyond its Amazonian origin, spurring a variety of legal and cultural responses in the countries to which it has spread. The essays in this volume look at how these responses have influenced ritual design and performance in traditional and non-traditional contexts, how displaced indigenous people and rubber tappers are engaged in the creative reinvention of rituals, and how these rituals help build ethnic alliances and cultural and political strategies for their marginalized position. Some essays explore important classic and contemporary issues in anthropology, including the relationship between the expansion of ecotourism and ethnic tourism and recent indigenous cultural revival and the emergence of new ethnic identities. The volume also examines trends in the commodification of indigenous cultures in post-colonial contexts, the combination of shamanism with a network of health and spiritually related services, and identity hybridization in global societies. The rich ethnographies and extensive analysis of these essays will allow deeper understanding of the role of ritual in mediating the encounter between indigenous traditions and modern societies.