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Bee venom, a complex mixture of proteins, has been found to have anti-thrombotic properties due to its components, including phospholipase and melittin, which impact blood clotting. Research has investigated the effects of honey bee venom (HBV, Apis mellifera) on human plasma proteins, revealing its potential as a natural pain relief agent. This has led to the development of bee venom pain relief creams and joint and bone therapy products, harnessing the venom's anti-inflammatory and anti-thrombotic properties to provide relief for various ailments.