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The contributions in this book explore various contexts in which the derived category of coherent sheaves on a variety determines some of its arithmetic. This setting provides new geometric tools for interpreting elements of the Brauer group. With a view towards future arithmetic applications, the book extends a number of powerful tools for analyzing rational points on elliptic curves, e.g., isogenies among curves, torsion points, modular curves, and the resulting descent techniques, as well as higher-dimensional varieties like K3 surfaces. Inspired by the rapid recent advances in our understanding of K3 surfaces, the book is intended to foster cross-pollination between the fields of complex algebraic geometry and number theory. Contributors: * Nicolas Addington* Benjamin Antieau * Kenneth Ascher * Asher Auel * Fedor Bogomolov * Jean-Louis Colliot-Thelene * Krishna Dasaratha * Brendan Hassett * Colin Ingalls* Marti Lahoz * Emanuele Macri * Kelly McKinnie * Andrew Obus * Ekin Ozman * Raman Parimala * Alexander Perry * Alena Pirutka * Justin Sawon * Alexei N. Skorobogatov * Paolo Stellari* Sho Tanimoto * Hugh Thomas * Yuri Tschinkel * Anthony Varilly-Alvarado * Bianca Viray * Rong Zhou