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This book addresses the complexity of urbanization, impacts of climate change and climate change adaptation for the metropolitan region of Santiago de Chile, with a special focus on the most pressing issues of natural hazards, water and energy supply. The book exemplifies a conceptual approach for the development of adaptation measures, their evaluation and implementation in a decision support framework at the science-policy interface. It builds on scientific analyses of social and natural scientists, a participatory process with local authorities and a mutual learning network between large agglomerations in Latin America. The book is written for scholars of urban management, climate change, planning, governance and hazard research, as well as practitioners in local, regional and international organizations concerned with climate change, climate change impacts, and adaptation in metropolitan regions. While the regional focus is on Latin America the concepts and lessons learned are applicable and relevant to megacities around the world.