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Papaya is a melon-likefruit, which varies greatly in shape and size. The skin of unripe fruit is smooth, green, and thin and changes to deep orange or yellow when ripe. The flesh varies from 2.5 to 5.0 cm in thickness and yellow to orange in color.Collect the Seeds: Collect fresh, mature seeds from a ripe papaya fruit. Scoop the seeds out of the fruit with a spoon and wash them in a strainer to remove any flesh or pulp. Soak the Seeds: Soak the seeds in a bowl of warm water for 24-48 hours.