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As the epidemic of diabetes continues to expand in parallel with the rapid spread of obesity, healthcare providers strive to find interventions to reduce the morbidity, mortality, and rising costs associated with this devastating disease, which ravages both the micro- and the macrovasculature. Although the increase in incidence of type 2 diabetes may be attributed to the expanding girth of the population coupled with a lack of physical activity, the marked increase in the incidence of type 1 diabetes remains unexplained. This book of Diabetes Mellitus will continue to be the most widely referenced textbook of diabetes worldwide and draws upon the expertise of leading basic scientists, clinicians, educators, and healthcare professionals globally to provide the most updated information on advances in diabetes research and clinical care. This information will be an invaluable resource and provide the practicing physician, as well as the basic scientist and clinical investigator, with the requisite resources to advance them to the frontiers of biomedical research in the fields of diabetes, metabolism, and obesity.