3 Review(s)

The National Research Council closes the landmark series Drinking Water and Health with Volume 9, published in two parts: Part I: DNA Adducts provides an overview of DNA adducts and their effects on human health, explores the techniques currently in use for detecting them, offers an outlook on future toxicity testing, and lists specific recommendations for action. Part II: Mixtures explores the issues surrounding multiple-chemical exposure from drinking water and reviews options for grouping compounds so their toxicity in mixtures can be reliably assessed. The book describes alternative approaches and considers the option of developing a modified "hazard index" for chemical compounds.Table of Contents Front Matter Part I: DNA Adducts Executive Summary 1 Biologic Significance of DNA Adducts and Protein Adducts 2 DNA-Adduct Technology 3 Conclusions and Recommendations Appendix A: Drinking Water Contaminant Candidates for Developmentof Baseline Data on Formation of DNA Adducts Glossary Biographical Sketches Part II: Mixtures Executive Summary 1 Introduction 2 Pharmacokinetics and the Risk Assessment of Drinking WaterContaminants 3 Risk Assessment of Mixtures of Systemic Toxicants in DrinkingWater 4 Assessment of Exposure to Organophosphorus Conpounds, Carbamates,and Volatile Organic Chemicals 5 Acetylcholinesterase Inhibitors: Case Study of Mixtures ofContaminates with Similar Biologic Effects 6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures ofPotentially Carcinogenic Chemicals 7 Conclusions and Recommendations for Research Appendix A: An Approach for Risk Assessment of Volatile OrganicChemicals in Drinking Water That Uses Experimental Inhalation Dataand a Physiologically Based Pharmacokinetic Model Appendix B: A Model Illustrating Synergism Appendix C: Models of Response: Dose Additivity and ResponseAdditivity Biographical Sketches Part III: Cumulative Index Index