3 Review(s)

Two key aspects of how the body handles drugs and other chemicals are metabolism and transport. The remarkable advances in molecular and cell biology and the development of novel in vitro model systems to study the various processes involved in metabolism and transport have expanded our knowledge and led to numerous, new therapeutic approaches to treatment of chemically-induced toxicity and disease. This book presents a collection of reviews on important topics in metabolism and transport. The editor has selected several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxtgenases, glutathione S-transferases, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present approaches to the study of signaling pathways in the regulation of drug metabolism enzymes and how modulation of these pathways can influence antiviral therapy. The transport chapters cover multidrug resistance proteins, the reduced folate carrier, and plasma membrane and mitochondrial glutatione transporters.