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This book constitutes the proceedings of the 6th International IFIP Working Conference on Research and Practical Issues of Enterprise Information Systems (CONFENIS 2012), held in Ghent, Belgium, during September 19-21, 2012. The theme of the conference was "enterprise information systems of the future -- evolving toward more performance through transparency and agility," mirroring the trend toward more open and more flexible systems. In all, 53 contributions were submitted and after a rigorous review process 10 full papers and 15 short papers were selected for publication in this book. These 25 papers present a well-balanced mix between the traditional social sciences and the novel design science paradigms in enterprise information systems research, and they also include practitioner-oriented and practice-driven contributions. The topics covered fall into three categories: information management in businesses (e.g., enterprise modeling or business process management), information systems from a management perspective (e.g., service innovation, business intelligence, or decision support systems), and ERP offerings and implementations (e.g., software as a service or ERP case studies).