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Essentials of Pharmacotherapeutics: Principles and Applications (D.Pharm Part-II) is a comprehensive academic resource designed to align with the Pharmacy Council of India (PCI) ER 2020 syllabus for Diploma in Pharmacy (D.Pharm) Part-II students. The book provides a structured understanding of pharmacotherapeutics, integrating fundamental pharmacological principles with their clinical applications to ensure rational and evidence-based drug therapy. It covers essential aspects such as mechanisms of action, pharmacokinetics, pharmacodynamics, therapeutic indications, contraindications, adverse drug reactions (ADRs), drug interactions, and monitoring parameters. A significant focus is placed on the rational use of medicines (RUM), patient-cantered care, and medication safety, preparing students to contribute effectively to healthcare settings. The book systematically discusses pharmacotherapy of major disease conditions affecting various organ systems, including cardiovascular, respiratory, gastrointestinal, endocrine, neurological, psychiatric, and infectious diseases, ensuring a holistic approach to treatment. Additionally, it includes contemporary topics such as clinical pharmacy practice, medication errors, Pharmacovigilance, and patient counselling, which are essential for modern pharmacy professionals. Case-based discussions and real-world clinical scenarios enhance problem-solving and decision-making skills, enabling students to apply theoretical knowledge in practical settings. With a concise yet academically rigorous approach, this book serves as a fundamental guide for D.Pharm students, equipping them with the necessary knowledge to excel in pharmacotherapeutics and contribute to optimized patient care.