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"European Collaboration: Towards Drug Development and Rational Drug Therapy " is the title of the 6th Congress of the European Association for Clinical Pharmacology and Therapeutics ( EACPT )being held in Istanbul,Turkey from June 24th -28th 2003. Istanbul has been chosen as the venue for this congress as a unique city bridging two continents and bringing together scientists from a large number of countries. This volume has been edited by Prof Cankat Tulunay ( the President of the Congress ) and Prof Michael Orme ( co-ordinator of the Scientific Committee and Hon. Secretary of EACPT. The volume contains details of the 21 symposia and 3 workshops that are taking place in Istanbul together with the abstracts from the more than 400 submitted and being presented in Istanbul. The organisers hope that you will enjoy both the scientific and cultural aspects of this Congress. Table of contents Abstracts of lectures 1 Table of abstracts 39 Abstracts 69 Abstracts of lectures 23 June 2003 Whole Day Course indeed it is important to stress that this process in Introduction to the Methodology of Clinical Trials a continuum, with useful information coming from different departments contributing day by Paola Antonini day to the final product profile. Key areas of Pre- Medical Affairs Director, Merck Sharp & Dohme clinical Development are Pharmacology, Toxicol- Italy ogy, Pharmacokinetics and Chemistry and Ph- macy.