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The aim of this book is to provide evidence-based information on the management of high-risk newborn infants. The book is not meant to be a comprehensive textbook of Neonatology. It is a handbook that will provide useful and practical information for the clinician who manages the sick newborn infants.Sick newborn infants represent a very high-risk population that carries high mortality and morbidity. Neonatal Intensive Care Units around the world have been built and staffed to take care of these sick newborns. Although many of the treatment modalities to improve their outcomes are based on solid data derived from basic science and clinical research, some are not and are simply based on anecdotal experience and clinicians' intuition and belief. This publication will elaborate and affirm the management strategies that are based on solid scientific evidence and discuss those that are not. The information will assist neonatologists and pediatricians in providing the best management options for various illnesses that affect this vulnerable population.