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This book is a resource for the identification, selection, implementation, and evaluation of evidence-based practices to promote positive outcomes for learners with autism spectrum disorder across the lifespan and enhance their quality of life. The book discusses the decision-making process for identifying and selecting evidence-based practices to address the academic, behavioral, and social needs of this population of learners. It provides a systematic description of the implementation and evaluation of evidence-based practices within the context of ongoing assessment and data-based decision making. It presents evidence-based training models for promoting the adoption and implementation with fidelity of evidence-based practices while highlighting an ethical decision-making model for solving dilemmas common to selecting, implementing, and evaluating evidence-based practices. The book underlines the importance of developing collaborative partnerships with families and other professionals to better address the needs to learners with autism spectrum disorder.