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Thoroughly revised and updated with the latest data from this ever-changing field, the eighth edition of Genetics: Analysis of Genes and Genomes provides a clear, balanced, and comprehensive introduction to genetics and genomics at the college level. Expanding upon the key elements that have made this text a success, Dr. Hartl has included updates throughout, as well as a new chapter dedicated to human genetic evolution. He continues to treat transmission genetics, molecular genetics, and evolutionary genetics as fully integrated subjects and provides students with an unprecedented understanding of the basic process of gene transmission, mutation, expression, and regulation. The beginning of each chapter includes a new section highlighting scientific competencies, while end-of-chapter Guide to Problem-Solving sections demonstrate the concepts needed to solve problems efficiently and understand the reasoning behind the correct answer. New and Key Features of the Eighth Edition: A new Chapter 19, Human Evolutionary Genetics. Learning Objectives & Scientific Competencies added to the beginning of each chapter. New problem sets in the accompanying ancillary material. Updated throughout with the latest data in this fast-paced field including new sections on Telomeric Length Limits and Number of Cell Doublings; CNV with Reciprocal Risks of Autism and Schizophrenia; Translation Proofreading and Premature Termination; Stochastic Noise in Gene Expression; Stochastic Noise in lac Expression; and Long Noncoding RNA (IncRNA). About the Author Daniel L. Hartl is Higgins Professor of Biology in the Department of Organismic and Evolutionary Biology at Harvard University. He has authored or coauthored more than 300 scientific articles and 20 books in genetics, genomics, molecular evolution, and population genetics. He has served as president of the Genetics Society of America and the Society for Molecular Biology and Evolution. He has also served as Chairman of his department at Harvard. He is was elected to the National Academy of Sciences and the American Academy of Arts and Sciences. He received his PhD from the University of Wisconsin. His research interests include evolutionary genomics, molecular evolution and population genetics. Table of Contents Genes, Genomes and Genetic Analysis DNA Structure and Genetic Variation Transmission Genetics: The Principle of Segregation Chromosomes and Sex-Chromosome Inheritance Genetic Linkage and Chromosome Mapping Molecular Biology of DNA Replication and Recombination Molecular Organization of Chromosomes Human Karyotypes and Chromosome Behavior Genetics of Bacteria and Their Viruses Molecular Biology of Gene Expression Molecular Mechanisms of Gene Regulation Genomics, Proteomics, and Transgenics Genetic Control of Development Molecular Mechanisms of Mutation and DNA Repair Molecular Genetics of the Cell Cycle and Cancer Mitochondrial DNA and Extranuclear Inheritance Molecular Evolution and Population Genetics The Genetic Basis of Complex Traits Human Evolutionary Genetics