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This book is the second volume in a new series on 'Great Minds in Regional Science,' which seeks to present a contemporary view on the scientific relevance of the work done by great thinkers in regional science. This volume presents, among others, Adam Smith, Johann Heinrich von Thuenen, and Alan Wilson. Each chapter combines factual biographical information about the 'Great Mind,' a description of their major contributions, and a discussion of the broader context of their work, as well as an assessment of its current relevance, scientific recognition, and policy impact. The book attempts to fill a gap in our knowledge and to respond to the growing interest in the formation and development of the field of regional science and its key influential figures.