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The Fourth Edition of Protective Groups in Organic Synthesis include updates on protective group chemistry from the years 1998 forward. In addition to incorporating any new protective groups now available to the synthetic organic chemist, the book also updates the old protective group content with new methodology discussing the installation and cleavage of protective groups. The fourth edition is comprehensive in the overall scope of coverage, and provides the most relevant and useful examples to illustrate each methodology. Protective Groups is a useful guide to the organic chemist, and the content is organized on the basis of the functional group to be protected (i.e., ethers, amides, phenols, phosphates, etc). Within each section, the organization goes from the simple protective groups to the most complicated (in terms of structure). About the Author Peter G. M. Wuts, PhD, is Senior Scientist at Pfizer in Kalamazoo, MI, and has a PhD in Chemistry from Northwestern University. The late Theodora W. Greene, PhD, is the former librarian for the Rowland Institute for Science and former assistant editor for Organic Syntheses. She received her PhD in Chemistry from Harvard University. Table of Contents Preface to the Fourth Edition. Preface to the Third Edition. Preface to the Second Edition. Preface to the First Edition. Abbreviations. 1. The Role of Protective Groups in Organic Synthesis. 2. Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols. Ethers. Esters. Protection for 1,2- and 1,3-Diols. 3. Protection for Phenols and Catechols. Protection for Phenols. Ethers. Silyl Ethers. Esters. Carbonates. Aryl Carbamates. Phosphinates. Sulfonates. Protection for Catechols. Cyclic Acetals and Ketals. Cyclic Esters. Protection for 2-Hydroxybenzenethiols. 4. Protection for the Carbonyl Group. Acetals and Ketals. Miscellaneous Derivatives. Monoprotection of Dicarbonyl Compounds. 5. Protection for the Carboxyl Group. Esters. Amides and Hydrazides. Protection of Boronic Acids. Protection of Sulfonic Acids. 6. Protection for the Thiol Group. Thioethers. Thioesters. Miscellaneous Derivatives. 7. Protection for the Amino Group. Carbamates. Amides. Special --NH Protective Groups. Protection for Imidazoles, Pyrroles, Indoles, and other Aromatic Heterocycles. Protection for the Amide --NH. Protection for the Sulfonamide --NH. 8. Protection for the Alkyne --CH. 9. Protection for the Phosphate Group. Some General Methods for Phosphate Ester Formation. Removal of Protective Groups from Phosphorus. Alkyl Phosphates. Phosphates Cleaved by Cyclodeesterifi cation. Benzyl Phosphates. Phenyl Phosphates. Photochemically Cleaved Phosphate Protective Groups. Amidates. Miscellaneous Derivatives. 10. Reactivities, Reagents, and Reactivity Charts. Reactivities. Reagents. Reactivity Charts. Protection for the Hydroxyl Group: Ethers. Protection for the Hydroxyl Group: Esters. Protection for 1,2- and 1,3-Diols. Protection for Phenols and Catechols. Protection for the Carbonyl Group. Protection for the Carboxyl Group. Protection for the Thiol Group. Protection for the Amino Group: Carbamates. Protection for the Amino Group: Amides. Protection for the Amino Group: Special --NH Protective Groups. Selective Deprotection of Silyl Ethers. Index.