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This volume presents the proceedings of the IFIP TC2 WG 2.5 Conference on Grid-Based Problem Solving Environments: Implications for Development and Deployment of Numerical Software, held in Prescott, Arizona from July 17-21, 2006. The book contains the most up-to-date research on grid-based computing. It will interest users and developers of both grid-based and traditional problem solving environments, developers of grid infrastructure, and developers of numerical software.