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This volume, based on the second international symposium on hemophilia held in Rome, includes not only the presented material but also other significant contributions by fifty-five of the most outstanding workers in the field. A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value.