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This book constitutes the refereed proceedings of the Second International Conference on Intelligent, Secure, and Dependable Systems in Distributed and Cloud Environments, ISDDC 2018, held in Vancouver, BC, Canada, in November 2018. The 10 full papers were carefully reviewed and selected from 28 submissions. This book also contains the abstracts of two keynote talks and one tutorial. The contributions included in this proceedings cover many aspects of theory and application of effective and efficient paradigms, approaches, and tools for building, maintaining, and managing secure and dependable systems and infrastructures, such as botnet detection, secure cloud computing and cryptosystems, IoT security, sensor and social network security, behavioral systems and data science, and mobile computing.