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This book represents the peer-reviewed proceedings of the Second International Symposium on Intelligent Distributed Computing - IDC 2008 held in Catania, Italy during September 18-19, 2008. The 35 contributions in this book address many topics related to intelligent and distributed computing, systems and applications, including: adaptivity and learning; agents and multi-agent systems; argumentation; auctions; case-based reasoning; collaborative systems; data structures; distributed algorithms; formal modeling and verification; genetic and immune algorithms; grid computing; information extraction, annotation and integration; network and security protocols; mobile and ubiquitous computing; ontologies and metadata; P2P computing; planning; recommender systems; rules; semantic Web; services and processes; trust and social computing; virtual organizations; wireless networks; XML technologies.