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The book focuses on the novel and unexplored research area of intersection between science, technology, and innovation and international affairs. The main objective of this book is to offer an original theoretical, analytical, and methodological framework that provides a wide comprehensive map of the current reality of science, tech, and innovation in the world system at the beginning of the twenty-first century. The book is based on 10 years of research work in the strategic intersection between science, technology, and innovation and international relations, and offers new explanations about three main issues: (1) the role of science, tech, and innovation in the current international system, (2) the new configuration of international scientific relations, and (3) the impact and consequences of science, technology, and innovation in the world order of the twenty-first century.