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The book discusses the opportunities and challenges of managing knowledge in the new reality of Industry 4.0. Addressing paradigmatic changes in value creation due to the development of digital technologies applied to manufacturing (additive manufacturing, IoT, robotics, etc.), it includes theoretical and empirical contributions on how Industry 4.0 technologies allow firms to create and exploit knowledge. The carefully selected expert contributions highlight the potential of these technologies in acquiring knowledge from a larger number of sources and examine approaches to innovation, organization of activities, and stakeholder development in the context of this next industrial revolution.