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Om Mani PadMe Hum (derived from Sanskrit) is the most widely-known and popular mantra used in Buddhism. âOm Mani PadMe Humâ (derived from Sanskrit) is the most widely-known and popular mantra used in Buddhism. This six syllable phrase which can be transliterated to "Hail the Jewel in the Lotus" is an invocation mantra of the Avalokiteshvara, the Bodhisattva of Infinite Compassion who protects one from harm. The Bodhisattva vowed to free all sentient beings from suffering and is said to appear anywhere to help all beings in danger and distress. Om Mani PadMe Hum is also referred to as "The Mantra of Universal Protection". IT IS BELEIVED THAT CHANTING OF THIS MANTRA BRIGS PROSPERITY ,HEALTH AND WEALTH