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The authors of this comprehensive book provide a detailed rationale and original theory for the study of leadership and institutional factors, including entrepreneurship, in the growth and development of cities and regions. They demonstrate why leadership, institutions and entrepreneurship can - and indeed do - play a crucial enhancing role as key elements in the process of regional endogenous growth. The so-called 'new growth theory' emphasizes endogenous processes. While some of the literature refers to leadership and institutional factors, there has been little analysis of the explicit roles these factors play in the growth and development of cities and regions. This book remedies that gap, beginning with a brief overview of the evolution of the 'new growth theory' in regional economic development, in which the emphasis is on endogenous factors. The book then discusses leadership and institutional factors in that context, creating a new path for understanding regional economic development processes. Multiple case studies from different parts of the world illustrate the theoretical concepts. Students and scholars in regional development, planning and public policy will find this volume invaluable.