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Molecular Biology is a rapidly advancing field with a constant flow of new information and cutting-edge developments that impact our lives. Lewin’s GENES has long been the essential resource for providing the teaching community with the most modern presentation to this dynamic area of study. Lewin"s GENES XI continues this tradition by introducing the most current data from the field, covering gene structure, sequencing, organization, and expression. A wealth of subject-matter experts, from top institutions, to provide content updates and revisions in their individual areas of study. A reorganized chapter presentation provides a clear, more student-friendly introduction to course material than ever before.   New and Key Features of Lewin"s GENES XI: Updated content throughout to keep pace with this fast-paced field Reorganized chapter presentation provides a clear, student-friendly introduction to course material Expanded coverage describing the connection between replication and the cell cycle is included, and presents eukaryotes as well as prokaryotes A wealth of pedagogical features throughout the text help student to understand better and retain important data. About the Author Jocelyn E. Krebs has been a member of the Department of Biological Sciences at the University of Alaska Anchorage since 2000. She received her B.A. in Biological Sciences from Bard College in 1991 and her PhD in Molecular and Cell Biology from the University of California Berkeley in 1997. Her research focuses on the mechanisms by which DNA transactions such as transcription and repair are accomplished in the context of chromatin. Her teaching interests are in Molecular Biology (taught at the undergraduate, graduate, and first-year medical school levels), as well as the Molecular Biology of Cancer. Stephen T. Kilpatrick is an Associate Professor of Biology at the University of Pittsburgh at Johnstown (UPJ). He received a B.S. in Biology for Eastern College (now Eastern University) and a PhD from the Program in Ecology and Evolutionary Biology at Brown University. His research an teaching interests are in evolutionary molecular genetics. UPJ is an undergraduate degree-granting campus of the University of Pittsburgh, and Dr. Kilpatrick regularly teaches undergraduate courses in majors introductory biology, genetics, evolution, molecular genetics, and biostatistics. Prior to coauthoring the Second Edition of Lewin’s Essential Genes, Dr. Kilpatrick has co-authored the test banks for the first edition and for Lewin’s GENES VIII and GENES IX. He has also authored ancillaries and pedagogical materials for several introductory non-majors and majors biology and genetics textbooks. Elliott S. Goldstein earned his B.S. in Biology from the University of Hartford (Connecticut) and his Ph.D. in Genetics from the University of Minnesota, Department of Genetics and Cell Biology. Following this, he was awarded an N.I.H. Postdoctoral Fellowship to work with Dr. Sheldon Penman at the Massachusetts Institute of Technology. Leaving Boston, he joined the faculty at Arizona State University in Tempe, where he is an Associate Professor in the Cellular, Molecular and Biosciences program in the School of Life Sciences, and in the Honors Disciplinary Program. His research interests are in the area of molecular and developmental genetics of early embryogenesis in Drosophila melanogaster. In recent years, he has focused on the Drosophila counterparts of the human proto-oncogenes jun and fos. His primary teaching responsibilities are in the undergraduate General Genetics course as well as the graduate level Molecular Genetics course. Table of Contents Part 1: Genes and Chromosomes Chapter 1: Genes Are DNA Chapter 2: Genes Encode RNAs and Polypeptides Chapter 3: Methods in Molecular Biology and Genetic Engineering Chapter 4: The Interrupted Gene Chapter 5: The Content of the Genome  Chapter 6: Genome Sequences and Gene Numbers   Chapter 7: Clusters and Repeats  Chapter 8: Genome Evolution  Chapter 9: Chromosomes  Chapter 10: Chromatin    Part 2: DNA Replication and Recombination Chapter 11: Replication Is Connected to the Cell Cycle  Chapter 12: The Replicon: Initiation of Replication   Chapter 13: DNA Replication  Chapter 14: Extrachromosomal Replicons Chapter 15: Homologous and Site-Specific Recombination   Chapter 16: Repair Systems   Chapter 17: Transposable Elements and Retroviruses  Chapter 18: Somatic Recombination and Hypermutationin the Immune System    Part 3: Transcription and Posttranscriptional Mechanisms Chapter 19: Prokaryotic Transcription   Chapter 20: Eukaryotic Transcription  Chapter 21: RNA Splicing and Processing    Chapter 22: mRNA Stability and Localization  Chapter 23: Catalytic RNA  Chapter 24: Translation   Chapter 25: Using the Genetic Code    Part 4: Gene Regulation Chapter 26: The Operon  Chapter 27: Phage Strategies  Chapter 28: Eukaryotic Transcription Regulation  Chapter 29: Epigenetic Effects Are Inherited  Chapter 30: Regulatory RNA