3 Review(s)

Combining principles of modern immunology with applications to immunopathology, this reference documents developments in the immunotherapy of autoimmune diseases - emphasizing monoclonal antibody and peptide approaches. Detailing possible antigen-specific manoeuvres, from targeting the T-cell receptor itself to intervening at the level of the major histocompatibility complex (MHC) antigens, "Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases": provides an update on T-cell basic science; discusses most monoclonal antibodies used in autoimmune disease experiments; describes the concept of peptide therapy in its various forms; and presents fundamental pharmacological data that clarify the clinical usage of these new agents. Containing over 1100 literature citations, "Monoclonal Antibodies and Peptide Therapy in Autoimmune Diseases" should be a useful resource for immunologists, rheumatologists, pharmacologists, pathologists, dermatologists, nephrologists, and graduate and medical school students in these disciplines.