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Motor neurone disease (amyotrophic lateral sclerosis) is one of several neurological diseases of unknown cause. It is an illness that rarely runs in families, nor do epidemics occur. It is therefore likely to be due to a multifactorial process, probably with a genetically determined susceptibility to some environmental insult. Provided in this book is a comprehensive and up-to-date text on motor neurone disease. It covers many aspects of the disease, including clinical descriptions and discussions on management of both early and late cases. Personal views of a carer are also included as well as the aetiology and molecular basis of this disease.