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Operations Research and Cyber-Infrastructure is the companion volume to the Eleventh INFORMS Computing Society Conference (ICS 2009), held in Charleston, South Carolina, from January 11 to 13, 2009. It includes 24 high-quality refereed research papers. As always, the focus of interest for ICS is the interface between Operations Research and Computer Science, and the papers in this volume reflect that interest. This is naturally an evolving area as computational power increases rapidly while decreasing in cost even more quickly, and the papers included here illustrate the wide range of topics at this interface.