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Sky fruit is commonly used as herbal remedy that helps improve blood circulation, treat diabetes, and cure impotence. Many people have already used it and anecdotal reports have recorded the health benefits of the fruit. Besides, the revelation of various substances that the fruit contains may give reliable scientific clues of how efficacious the fruit is and how numerous sky fruit health benefits. Sky fruit benefits can be revealed by looking into the health effects of chemical substances that the fruit contains. There are at least three active ingredients of sky fruit that are known to be beneficial for the health: flavonoid, saponin and alkaloids. We will look into the health benefits of the three active ingredients below. Flavonoid is a phenolic compound that contains many pigments of the plant. Flavonoid is beneficial for human especially because it is an antioxidant that exterminates free radicals and toxins and improves immune system. The anti-oxidizing properties of the flavonoid content of sky fruit make the fruit effective for fighting various diseases caused directly or indirectly by oxidation, such as LDL buildup, heart problem. The health benefits of the flavonoid content of sky fruit are briefly explained as follows.Flavonoid improves cardiovascular system by smoothing blood circulation, clearing blood vessels from clogging cholesterol, and preventing arteriosclerosis plague.Flavonoid has anti-inflammatory properties that prevent tissue inflammation. Flavonoid acts as painkiller that numbs pain caused by tissue injury.