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This detailed book explores protocols with the aim of testing aerobic exercise, resistance training, special diets, additives and natural products, which have led to new insights into the physiological and molecular aspects of health and disease. Many of these approaches have contributed to significant improvements in disease areas such as cardiovascular disease, cognitive dysfunction, diabetes, frailty, gliobastoma, metabolic syndrome, obesity, oxidative stress, and various cancers. This collection also provides important information on disease mechanisms and novel drug targets as each protocol is presented in the context of specific chronic diseases or different therapeutic areas. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and reflective of research from all around the globe, Physical Exercise and Natural and Synthetic Products in Health and Disease serves as an ideal guide for researchers in the areas of chronic disease, exercise, and nutrition, as well as to clinical scientists, physicians, and pharmacologists as it gives insights into possibilities for the development of novel therapeutics and the means of monitoring therapeutic response through the measurement of molecular and physiometric biomarkers.