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This book describes the principles, methods, and applications of PBPK modeling in the pharmaceutical industry. It addresses a growing need, as more and more pharma companies are integrating PBPK into their lead selection cycle and clinical development. Moving easily from theory to practice, the author presents coverage of both the principles and applications of PBPK modeling, exposing the power of this tool to improve the process of drug discovery and development. With end-of-chapter glossaries, extensive bibliographic references, and an emphasis on practical applications, this resource provides a much-needed single source for this important area.