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This volume constitutes the proceedings of the Third Working Conference on Practice-Driven Research on Enterprise Transformation (PRET), held in Luxembourg, on September 6, 2010, as the industrial track of the 13th IEEE Conference on Commerce and Enterprise Computing (CEC 2011). The third edition of PRET marks a close collaboration between academia and practice. With the specific purpose of mutual learning and crossfertilization, top practitioners from industry were invited to submit case studies. To give them enough space for presentation, only four academic papers were accepted. These papers were submitted with a length of 25 pages to enable a more detailed coverage of the related research and to stimulate further discussions during the conference. The topics covered are Enterprise Architecture, Business and IT Alignment, and Business Process Management and Evaluation.