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This book brings together the emerging trends and techniques incorporated in regional science during the first two decades of this millennium. The book includes systematic and analytical notes making scientific commentary on the innovative methods of regional development, measurement of the development, regional development models, and policy measures that have significant implications and wide applicability instrumental for India as well as the other global south countries. There is clear evidence in the global south of the uneven spatial distribution of resources, economic activities, literacy, and health conditions. The most striking fact is the coexistence of development and underdevelopment that makes the planning process complicated. This can hardly be explored without taking a deep insight into the matter of how the regional parameters are impacting regional society or economy to shape the development of that region. There can be no effective global policy framework that will be effective equally for each and every region to mitigate local issues of society or economy. It is here that the book integrates the efforts of practitioners working towards addressing these regional issues and striving for sustainable regional development through their innovative ideas. Through its contributions, the book addresses development issues, regional impact of climate change, social justice, migration, well-being, livelihood vulnerabilities, and regional urban-environmental issues from the standpoint of regional science. It is a significant resource for researchers of spatial science, and policy makers.