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This Safety Guide provides recommendations on meeting the requirements established in the IAEA International Basic Safety Standards, for protection of the public against exposure indoors due to natural sources of radiation. Guidance is provided on the application of the requirements for justification and optimization of protection by national authorities in considering control of natural sources of radiation indoors such as radon and radionuclides of natural origin in materials used for the construction of dwellings, offices, industrial premises and other buildings. The Safety Guide provides recommendations and guidance to be followed by the regulatory body and by other authorities and organizations with responsibilities in relation to exposure to radiation from natural sources.