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The volume is from the proceedings of the international conference held in celebration of Stanley Osher's sixtieth birthday. It presents recent developments and exciting new directions in scientific computing and partial differential equations for time dependent problems and their interplay with other fields, such as image processing, computer vision and graphics. Over the past decade, there have been very rapid developments in the field. This volume emphasizes the strong interaction of advanced mathematics with real-world applications and algorithms. The book is suitable for graduate students and research mathematicians interested in scientific computing and partial differential equations.