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This book presents selected papers from the MENDEL conference that was held in Brno, Czech Republic in June 2017. Consisting of two parts, the book discusses recent advances in soft computing, including intelligent image processing: Part 1 addresses evolutionary computing, swarm intelligence, metaheuristics, and optimization; Part 2 then focuses on neural networks, machine learning, self-organization, fuzzy systems, and advanced statistics.The MENDEL conference was established in 1995 and it bears the name of the scientist and Augustinian priest Gregor J. Mendel, who discovered the famous Laws of Heredity. The main aim of the conference was to create a regular opportunity for students, academics and researchers to exchange their ideas and novel research methods.