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This book provides an overview of the GLOWA-Danube research project from 2001 to 2011, a transdisciplinary initiative which explores the future of water resources in the Upper Danube Basin. It documents the purpose and unique approach, architecture, methodologies, scenarios and results of the project, creating a scientific knowledge base for the dialogue of stakeholders and scientists. The book offers a possible blueprint for successful global change science through integrative and transdisciplinary co-creation of knowledge and orientation for regional adaptation within the context of the Future Earth research program.