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Providing an up-to-date overview of the field, this state-of-the-art reference details how sleep and circadian rhythms are interconnected, revealing the impact of various disease states on, and the molecular and genetic basis for, disrupted sleep and circadian rhythmicity and their effects on physical and mental health, safety, performance, and productivity. Integrates current and rapidly advancing discoveries of sleep and circadian rhythms! Offering an integrative approach to research findings from basic science to clinical points of view, Regulation of Sleep and Circadian Rhythms discusses the three developmental stages of sleep in mammals the evolution of circadian timing brainstem regulation of sleep non-REM sleep and thalamocortical function cognitive correlates of behavioral states dysfunctional sleep sleep homeostasis neuroanatomy of circadian control acute effects of light organization of vertebrate circadian timing systems production, sites, and mechanisms of melatonin genetic aspects of pathological human sleep sleep alterations associated with age, disease, and psychiatric state and more! Complete with over 3200 references, tables, and figures, Regulation of Sleep and Circadian Rhythms is an essential resource for clinical neurologists and neurobiologists, pulmonologists, psychiatrists and behavioral scientists, endocrinologists and neuroendocrinologists, chronobiologists, sleep specialists, general medicine practitioners and internists, gerontologists, psychologists, and graduate and medical school students in these disciplines.