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This collection of essays is the first book published in English to provide a thorough survey of the practices of science in the Spanish and Portuguese empires from 1500 to 1800. Authored by an interdisciplinary team of specialists from the United States, Latin America, and Europe, the book consists of fifteen original essays, as well as an introduction and an afterword by renowned scholars in the field. The topics discussed include navigation, exploration, cartography, natural sciences, technology, and medicine. This volume is aimed at both specialists and non-specialists, and is designed to be useful for teaching. It will be a major resource for anyone interested in colonial Latin America.