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Glucosamine is a natural compound found in cartilage . glucosamine is harvested from shells of shellfish or made in a lab. it gives relief for mild to moderate knee osteoarthritis, and it will work for other joints, too. The glucosamine in your body helps keep up the health of your cartilage. But as you get older, your levels of this compound begin to drop, which leads to the gradual breakdown of The joint. There's some evidence that glucosamine sulfate supplements help counter act this effect, although experts aren't sure how Some people have also used glucosamine to try to treat rheumatoid arthritis and other conditions, such as inflammatory bowel disease, sports injuries, temporary mandibular joint problems, and long-term low back pain. Glucosamine sulfate is a chemical found in the human body. It is used by the body to produce a variety of other chemicals that are involved in building tendons, ligaments, cartilage, and the thick fluid that surrounds joints. This results in more joint friction, pain, and stiffness. Researchers think that taking glucosamine supplements may either increase the cartilage and fluid surrounding joints or help prevent breakdown of these substances, or maybe both.