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Clean the glass in your picture frames on a regular basis. In fact, it's a good idea to clean your picture frames every time you dust. Don't just wipe your dust rag over the glass, however. Use a glass cleaner or a mixture of vinegar and water to make them really sparkle.Clean both sides of the glass with a soft rag, not a paper towel, which can leave fibers and even scratch the glass. Use a commercial glass-cleaning product or a solution made of 2 cups of water, 1/4 cup of distilled white vinegar and a squirt of liquid dish soap.Handle the glass by the edges while it dries. Then, place it back into the frame. Add the photo and close it up securely by bending the tabs back into place.