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This book presents a selection of advanced case studies that cover a substantial range of issues and real-world challenges and applications in space engineering. Vital mathematical modeling, optimization methodologies and numerical solution aspects of each application case study are presented in detail, with discussions of a range of advanced model development and solution techniques and tools. Space engineering challenges are discussed in the following contexts: *Advanced Space Vehicle Design *Computation of Optimal Low Thrust Transfers *Indirect Optimization of Spacecraft Trajectories *Resource-Constrained Scheduling, *Packing Problems in Space *Design of Complex Interplanetary Trajectories *Satellite Constellation Image Acquisition *Re-entry Test Vehicle Configuration Selection *Collision Risk Assessment on Perturbed Orbits *Optimal Robust Design of Hybrid Rocket Engines *Nonlinear Regression Analysis in Space Engineering *Regression-Based Sensitivity Analysis and Robust Design*Low-Thrust Multi-Revolution Orbit Transfers *Modeling and Optimization of Balance Layout Problems *Pilot-Induced Oscillations Alleviation *Modeling and Optimization of Hybrid Transfers to Near-Earth Objects *Probabilistic Safety Analysis of the Collision Between Space Debris and Satellite *Flatness-based Low-thrust Trajectory Optimization for Spacecraft Proximity Operations The contributing authors are expert researchers and practitioners in either the space engineering and/or in the applied optimization fields. Researchers and practitioners working in various applied aspects of space engineering will find this book practical and informative. Academics, graduate and post-graduate students in aerospace engineering, applied mathematics, operations research, optimization, and optimal control, will find this book useful.